Sialic Acid in Murine

=> Sialic acid is a major component of airway glycoconjugates.
 * Sialic acid is identified as the host-derived metabolite that stimulates SP proliferation (SIEGEL; ROCHE; WEISER, 2014).
 * IV infection increases sialic acid and sialylated mucin availability and enhances desialylation of host glycoconjugates (SIEGEL; ROCHE; WEISER, 2014).
 * SP genes for sialic acid catabolism are required for IV to promote bacterial growth (SIEGEL; ROCHE; WEISER, 2014).
 * Decreasing sialic acid availability in vivo by genetic deletion of the major airway mucin Muc5ac or mucolytic treatment limits IV-induced SP replication (SIEGEL; ROCHE; WEISER, 2014).