IMPACT OF VACCINATION


 * Vaccinating mice with the highly conserved nucleoprotein of IV also reduces H1N1-induced susceptibility to lethal bacterial infections (HAYNES et al., 2012).
 * Augmented IFN-g production produced during the recovery stage of IAV infection was completely suppressed in mice previously immunized with FluMist (SUN et al., 2011).
 * Seasonal FluMist treatment not only promoted resistance to pandemic IAV infection but also restored innate immunity against complicating secondary bacterial infections (SUN et al., 2011).
 * LAIV increased bacterial transmigration to and persistence within the middle ear. When colonization followed LAIV inoculation, a minimum LAIV incubation period of 4 days was required before bacterial transmigration commenced (MINA et al., 2014).
 * LAIV vaccination reverses normal bacterial clearance from the nasopharynx and significantly increases bacterial carriage densities of the clinically important bacterial pathogens SP (serotypes 19F and 7F) (MINA; MCCULLERS; KLUGMAN, 2014).
 * Vaccination with LAIV resulted in 2-to 5-fold increases in mean durations of bacterial carriage (MINA; MCCULLERS; KLUGMAN, 2014).
 * LAIV vaccination increases carriage density and duration nearly identical in all aspects to changes in bacterial colonizing dynamics following infection with WT IV (MINA; MCCULLERS; KLUGMAN, 2014).
 * LAIV, unlike WT IV, had no effect on severe bacterial disease or mortality within the LRT (MINA; MCCULLERS; KLUGMAN, 2014).